Manchester city centre in the St. James Buildings, mainly for medical science courses.
=== The Student Hub ===
This building opened in 2011 as a central student area, containing retail and catering outlets and IT facilities, as well as providing new accommodation for the Edge Hill Students' Union. It was formally opened by Sophie, Countess of Wessex on 15 October 2012.
=== Sports Centre ===
The current indoor and outdoor sports complex was opened in 2015 by Olympic heptathlete Katarina Johnson-Thompson.
=== Arts Centre ===
The Arts Centre houses the university's Performing Arts Department and the Rose and Studio Theatres. The Arts Centre was officially opened by British screenwriter and writer of the London 2012 Summer Olympics opening ceremony Frank Cottrell Boyce who is an Honorary Doctor of Literature at the university. The Arts Centre includes a 234-seat professional theatre (The Rose Theatre) and a 140-seat Studio Theatre.
=== Catalyst ===
Catalyst serves as the Students' library on the Ormskirk campus, as well as the student services and information centre. The original library, which opened in the 1990s, was replaced with a new purpose-built multi-storey building, located on the old running track, adjacent to the Wilson Centre, and equidistant between the Student Hub and Creative Edge Buildings, as part of a £36 million development. The £26 million building houses a study space that is 8,000 square metres, which is 50% larger than the old Library building. The development began in December 2016, when the old racing track was dug up. Catalyst opened on 9 July 2018.
=== Halls of Residence ===
The original Halls of Residence were 'named Stanley, Clough, Lady Margaret and John Dalton "in honour" of the Derby Family' and "of three individuals famous in the history of Lancashire and of Education" (Anne Jemima Clough was a pioneer of higher education for women, having founded Newnham College, Cambridge)'
Five Halls, opened in 1963 by Princess Margaret, are named after Lady Openshaw, Katherine Fletcher …