Association of Intercollegiate Athletics (NAIA), competing in the Wolverine–Hoosier Athletic Conference (WHAC) for most of its sports since the 1997–98 academic year; while its football team competes in the Mideast League of the Mid-States Football Association (MSFA).
Madonna competes in 21 intercollegiate varsity sports. Men's sports include baseball, basketball, bowling, cheerleading, cross country, football, golf, lacrosse, soccer and track & Field; women's sports include basketball, bowling, cheerleading, competitive dance, cross country, golf, lacrosse, soccer, softball, track & field and volleyball.
The campus features a renovated basketball and volleyball gymnasium, Alliance Catholic Credit Union Arena at the Performing Arts, Academics, and Athletics Center, with a capacity of 1,200; international-size soccer field, which hosts camps and tournaments; Ilitch Ballpark baseball field and fast-pitch softball field.
== Notable alumni ==
Lyn Bankes, member of the Michigan House of Representatives
Kerry Bentivolio, …
