Hamilton, Major League Baseball (MLB) outfielder
Hilton Koch, former owner of the WNBA's Houston Comets
Kareem Moore, NFL safety
Darryl Pounds, former NFL defensive back
Antonio Robinson, NFL wide receiver
Dwight Walker, former NFL running back and wide receiver
Lardarius Webb, NFL cornerback and return specialist
=== Other ===
Donald J. Boudreaux, economist and professor
Punkie Johnson, actress and stand-up comedian, featured player on Saturday Night Live from 2020 to 2024.
Kellyn LaCour-Conant, restoration ecologist
Cyril and Libbye Hellier, operatic sopranos
Andrew Simoncelli, WWL-TV producer, professor
Rocsi Diaz, talk show host of 106 & Park, Entertainment Tonight and ABC correspondent
== Notable faculty ==
Monnie T. Cheves (1902–1988), education professor; served in the Louisiana House of Representatives from Natchitoches Parish from 1952 to 1960
Thomas G. Clausen (1939–2002), the last elected Louisiana state superintendent of education, on Nicholls faculty from 1967 to 1972
Marilyn Kilgen (1944), microbiologist …
