17 miles (27 km) from the main campus, the site of SIU's Alton residential center from 1957 to 1965, now houses the School of Dental Medicine and its offices, classrooms, labs, clinics, and ancillary services.
The Alton campus is also home to the Alton Museum of History and Art, located inside Loomis Hall.
=== East St. Louis Center ===
SIUE's East St. Louis Center, located in East St. Louis, Illinois, 22 miles (35 km) from the main campus, traces its beginnings when Southern Illinois University Board of Trustees in response to local people's demands for more education in the Metro East established residence centers in East St. Louis in 1957. The current location is the center's fifth in the city since 1957, but it is the first site specifically designed and built for this purpose. The center provides educational programs, community outreach health services, and cultural events to an economically deprived area of the Metro East. It also provides clinical and practicum experiences relating to urban community …
