University of Indianapolis's athletic teams are known as the Greyhounds and participate in Division II of the NCAA. All 25 of the teams compete in the Great Lakes Valley Conference. The school's highest finish in the NACDA Directors' Cup was 2nd in 2023–24. UIndy has finished in the top 20 every year since 2006–7, including twelve top 10s in that span.
The mascot is a greyhound named Ace that is depicted in a statue in Schwitzer Student Center and represented at athletic events by a costumed mascot. Since 2019, UIndy has also had a live mascot, a retired racing greyhound named Grady. The university's song, called simply the "U of I Fight Song," was written in 1975 by James M. Stanton, at the time an Indiana Central senior. The lyrics were rewritten when the university changed its name in 1986.
== Notable alumni ==
Harold Achor (1928) – Justice of the Indiana Supreme Court
Jon Ackerson – lawyer and member of both houses of the Kentucky State Legislature
Brian Barnhart (1983) – president of Harding Steinbrenner …
