Silvius Piccolomini was chancellor of the university in his capacity as provost of Worms, and later always favored it with his friendship and good-will as Pope Pius II. In 1482, Pope Sixtus IV permitted laymen and married men to be appointed professors in the ordinary of medicine through a papal dispensation. In 1553, Pope Julius III sanctioned the allotment of ecclesiastical benefices to secular professors.
=== Reformation and modern era ===
Martin Luther's disputation at Heidelberg in April 1518 made a lasting impact, and his adherents among the masters and scholars soon became leading Reformationists in Southwest Germany. With the Electorate of the Palatinate turn to the Reformed faith, Otto Henry, Elector Palatine, converted the university into a calvinistic institution. In 1563, the Heidelberg Catechism was created under collaboration of members of the university's divinity school.
As the 16th century was passing, the late humanism stepped beside Calvinism as a predominant school of thought; and figures …
