D-II Independent for most of its sports since the 2016–17 academic year (which they were a member on a previous stint from 2010–11 to 2012–13); while being an associate member of the Eastern College Athletic Conference (ECAC) for some of its sports. The Tigers previously competed as a member of the Great Midwest Athletic Conference (G-MAC) from 2013–14 to 2015–16; as well as a charter member of the defunct West Virginia Intercollegiate Athletic Conference (WVIAC) from 1924–25 to 2009–10. They have also competed as a dual affliate with the United States Collegiate Athletic Association (USCAA) since the 2022–23 school year, thus winning national championships in men's basketball (2023), women's basketball (2024), and baseball (2025).
Salem competes in 14 intercollegiate varsity sports: Men's sports include baseball, basketball, soccer, swimming, tennis, wrestling, water polo; while women's sports basketball, soccer, softball, swimming, volleyball, tennis, and water polo.
=== Conference membership ===
Salem competed …
