11 times, including a trip to the Final Four in 1977. NBA players that once suited up for the 49ers include Boston Celtics Cedric Maxwell, DeMarco Johnson, 2001 NBA draft lottery pick Rodney White, Eddie Basden and Chad Kinch of the Cleveland Cavaliers.
=== Women's basketball ===
In 2003 the women's basketball team reached the NCAA Tournament for the first time. In the 2021–22 season, the team won both a CUSA regular season and tournament championship, resulting in an NCAA tournament berth.
=== Baseball ===
Charlotte Baseball has made six NCAA Tournament appearances with the most recent coming in 2021. The 49ers have four conference tournament championships, and eight regular season conference championships. Baseball alums with Major League experience include Bryan Harvey (Angels), Jeff Johnson (Yankees), Chris Haney (Kansas City Royals), John Maine (New York Mets), Jason Stanford (Cleveland Indians). Fieldin Culbreth is a recently retired MLB umpire who worked the 2008 World Series.
=== Football ===
Charlotte's …