was named for its approximate location in the geographic "centre" of the Commonwealth, using early-nineteenth-century America's contemporaneous spelling of the word. The legislature placed many of Kentucky's most prominent citizens in charge of Centre College's Board of Trustees, including James G. Birney, who represented Danville in the Kentucky House of Representatives, and chairman Isaac Shelby, the Commonwealth's first governor. Classes began in the fall of 1820 in Old Centre, the first building on campus and the oldest college administration building west of the Allegheny Mountains. The students were all male, a policy that would hold until 1930, and none were African-American, which would change only in 1961.
In its early years, Centre navigated financial hardships, disputes within and outside the Presbyterian Church, and six wars, including the occupation of Old Centre by both Confederate and Union troops during the Civil War. A Centre alumnus, John Todd Stuart, played a formative role in American history …